Worked example 1
In a population of 10,000 students, 1% are homozygous recessive for a particular genetic condition. Calculate the frequency of: (a) the recessive allele. (b) the dominant allele. (c) heterozygous individuals.
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We use the Hardy-Weinberg equations: p + q = 1 and p^2 + 2pq + q^2 = 1. Given: frequency of homozygous recessive genotype = 1% = 0.01.
(a) Recessive allele (q): We know that q^2 = frequency of homozygous recessive genotype. So, q^2 = 0.01 q = sqrt(0.01) q = 0.1 The frequency of the recessive allele is 0.1.
(b) Dominant allele (p): We know that p + q = 1. So, p + 0.1 = 1 p = 1 - 0.1 p = 0.9 The frequency of the dominant allele is 0.9.
(c) Heterozygous individuals (2pq): We know that the frequency of heterozygous individuals is 2pq. 2pq = 2 * 0.9 * 0.1 2pq = 0.18 The frequency of heterozygous individuals is 0.18 (or 18%).