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9990 · 1.1.2

Explanations of schizophrenia

9990 Clinical — biological, psychological, and sociocultural explanations of schizophrenia.

Need to know

What you need to know

  • Genetic vulnerability is shown by higher concordance rates in genetically similar individuals (e.g., MZ vs DZ twins).
  • Schizophrenia is considered polygenic, meaning multiple genes contribute to the risk.
  • Neural correlates are observable differences in the brain, such as enlarged ventricles and reduced grey matter.
  • Reduced activity in the ventral striatum is linked to avolition (a negative symptom).

Explanation

Explanations of schizophrenia

  1. Genetic vulnerability is shown by higher concordance rates in genetically similar individuals (e.g., MZ vs DZ twins).
  2. Schizophrenia is considered polygenic, meaning multiple genes contribute to the risk.
  3. Neural correlates are observable differences in the brain, such as enlarged ventricles and reduced grey matter.
  4. Reduced activity in the ventral striatum is linked to avolition (a negative symptom).