9990 · 1.2.2
Explanations of mood (affective) disorders: depressive disorder (unipolar)
9990 Clinical — biological, cognitive, and psychodynamic explanations of unipolar depression.
Need to know
What you need to know
- Genetic predisposition: Higher concordance rates in MZ twins than DZ twins indicate a heritable component.
- Monoamine hypothesis: Depression is linked to a functional deficit of serotonin, noradrenaline, and dopamine.
- Neurochemical function: Low serotonin affects mood regulation; low noradrenaline affects alertness and energy.
- Supporting evidence: The effectiveness of antidepressant drugs (e.g., SSRIs) that increase serotonin levels in the synapse provides support for this explanation.
Explanation
Explanations of mood (affective) disorders: depressive disorder (unipolar)
- Genetic predisposition: Higher concordance rates in MZ twins than DZ twins indicate a heritable component.
- Monoamine hypothesis: Depression is linked to a functional deficit of serotonin, noradrenaline, and dopamine.
- Neurochemical function: Low serotonin affects mood regulation; low noradrenaline affects alertness and energy.
- Supporting evidence: The effectiveness of antidepressant drugs (e.g., SSRIs) that increase serotonin levels in the synapse provides support for this explanation.