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9990 · 1.2.2

Explanations of mood (affective) disorders: depressive disorder (unipolar)

9990 Clinical — biological, cognitive, and psychodynamic explanations of unipolar depression.

Need to know

What you need to know

  • Genetic predisposition: Higher concordance rates in MZ twins than DZ twins indicate a heritable component.
  • Monoamine hypothesis: Depression is linked to a functional deficit of serotonin, noradrenaline, and dopamine.
  • Neurochemical function: Low serotonin affects mood regulation; low noradrenaline affects alertness and energy.
  • Supporting evidence: The effectiveness of antidepressant drugs (e.g., SSRIs) that increase serotonin levels in the synapse provides support for this explanation.

Explanation

Explanations of mood (affective) disorders: depressive disorder (unipolar)

  1. Genetic predisposition: Higher concordance rates in MZ twins than DZ twins indicate a heritable component.
  2. Monoamine hypothesis: Depression is linked to a functional deficit of serotonin, noradrenaline, and dopamine.
  3. Neurochemical function: Low serotonin affects mood regulation; low noradrenaline affects alertness and energy.
  4. Supporting evidence: The effectiveness of antidepressant drugs (e.g., SSRIs) that increase serotonin levels in the synapse provides support for this explanation.